Article
Animal models of myocardial infarction: Mainstay in clinical translation.
Regulatory toxicology and pharmacology : RTP - 1 Apr 2016
Kumar Mukesh, Kasala Eshvendar Reddy, Bodduluru Lakshmi Narendra, Dahiya Vicky, Sharma Dinesh, Kumar Vikas, Lahkar Mangala
Abstract excerpt
Preclinical models with high prognostic power are a prerequisite for translational research. The closer the similarity of a model to myocardial infarction (MI), the higher is the prognostic value for clinical trials. An ideal MI model should present cardinal signs and pathology that resemble the human disease. The increasing understanding of MI stratification and etiology, however, complicates the choice of...
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