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Article

Regulation of extrasynaptic 5-HT by serotonin reuptake transporter function in 5-HT-absorbing neurons underscores adaptation behavior in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2011

Jafari Gholamali, Xie Yusu, Kullyev Andrey, Liang Bin, Sze Ji Ying

Abstract excerpt

Serotonin [5-hydroxytryptamine (5-HT)]-absorbing neurons use serotonin reuptake transporter (SERT) to uptake 5-HT from extracellular space but do not synthesize it. While 5-HT-absorbing neurons have been identified in diverse organisms from Caenorhabditis elegans to humans, their function has not been elucidated. Here, we show that SERT in 5-HT-absorbing neurons controls behavioral response to food deprivation in...

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Identifiers

PMID: 21677178
DOI: 10.1523/JNEUROSCI.1692-11.2011
PMCID: PMC3153855

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Source receipt: pubmed, retrieved 7 Sept 2026.

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