Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delayed effects of tamoxifen in hepatocarcinogenesis-resistant Fischer 344 rats as compared with susceptible strains.

Cancer letters - 28 Sept 2001

Stanley L A, Carthew P, Davies R, Higginson F, Martin E, Styles J A

Abstract excerpt

The anti-oestrogenic drug tamoxifen has been under investigation as a breast cancer chemopreventive agent for at least a decade. However, its use for this purpose is still debatable since it is able to induce liver tumours in rats via a mechanism involving metabolic activation to a DNA adduct-forming electrophilic intermediate. The metabolic activation and adduct-forming properties of tamoxifen are now well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Cell Size
Share to Cocarcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Adducts

Share to Liver Neoplasms, Experimental

Share to Rats, Inbred F344

Share to Rats, Inbred Lew

Share to Tamoxifen

Source

Identifiers

PMID: 11485825
DOI: 10.1016/s0304-3835(01)00564-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delayed effects of tamoxifen in hepatocarcinogenesis-resistant Fischer 344 rats as compared with susceptible strains.PMID 11485825Read ↗

Review of the toxicology of tamoxifen.Semantic proximity Read ↗

Short-term dosing of alpha-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han rats.Semantic proximity Read ↗

Risk assessment of non-genotoxic carcinogens.Semantic proximity Read ↗

Role of cell proliferation at early stages of hepatocarcinogenesis.Semantic proximity Read ↗

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced HepatocarcinogenesisSemantic proximity Read ↗

Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo.Semantic proximity Read ↗

Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture.Semantic proximity Read ↗

DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.Semantic proximity Read ↗

Dehydroepiandrosterone is a complete hepatocarcinogen and potent tumor promoter in the absence of peroxisome proliferation in rainbow trout.Semantic proximity Read ↗

Cyproterone acetate: a genotoxic carcinogen?Semantic proximity Read ↗

Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes.Semantic proximity Read ↗

Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.