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DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.

Carcinogenesis - 1 Aug 2001

Gamboa da Costa G, McDaniel-Hamilton L P, Heflich R H, Marques M M, Beland F A

Abstract excerpt

The non-steroidal anti-estrogen tamoxifen is used as an adjunct chemotherapeutic agent for the treatment of all stages of breast cancer and more recently as a chemoprotective agent in women with elevated risk of developing breast cancer. While beneficial for the treatment of breast cancer, tamoxifen increases the risk of endometrial cancer. In addition, it has been shown to induce liver and endometrial tumors in...

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PMID: 11470763
DOI: 10.1093/carcin/22.8.1307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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