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Article

Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen.

Cancer letters - 8 Feb 2002

Gamboa da Costa Gonçalo, Manjanatha Mugimane G, Marques M Matilde, Beland Frederick A

Abstract excerpt

The antiestrogen tamoxifen is carcinogenic in the liver and uterus of rats. Liver tumors appear to result from sequential hydroxylation and esterification of the alpha-carbon of tamoxifen followed by DNA adduct formation. The mechanism for the induction of uterine tumors is not known. Big Blue rats were treated by intraperitoneal injection with 21 daily doses of 54 micromol/kg tamoxifen or its proximate...

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PMID: 11790452
DOI: 10.1016/s0304-3835(01)00741-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen.PMID 11790452Read ↗

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