Review of the toxicology of tamoxifen.

Article

Review of the toxicology of tamoxifen.

Seminars in oncology - 1 Feb 1997

Wogan G N

Abstract excerpt

Tamoxifen was carcinogenic to the liver of male and female rats, inducing hepatocellular carcinomas when administered daily by gavage or fed continuously in the diet. It also acted as a promoting agent in a two-stage model of carcinogenesis in rat liver. In contrast, tamoxifen acted as a protecti...

Topics

Animals
Antineoplastic Agents, Hormonal
Carcinogenicity Tests
DNA Adducts
Genes, p53
Humans
Liver Neoplasms
Mice
Mutation
Rats
Risk Assessment
Tamoxifen

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