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Article

The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2001

Lottermoser K, Düsing R, Ervens P, Koch B, Brüning T, Sachinidis A, Vetter H, Ko Y

Abstract excerpt

Accumulating evidence suggests that plasma levels of the plasminogen activator inhibitor 1 (PAI-1) may modulate the risk of coronary artery disease. The regulation of PAI-1 levels underlies not only environmental but also genetic influences. The 4G/5G polymorphism of the PAI-1 gene has recently gained additional relevance as a possible cardiovascular risk factor, as the 4G allele may be associated with enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11485022
DOI: 10.1007/s001090100192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians.PMID 11485022Read ↗

Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly.Semantic proximity Read ↗

Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction.Semantic proximity Read ↗

4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke.Semantic proximity Read ↗

Allelic frequency of the PAI-1 4G/5G promoter polymorphism in patients with type 2 diabetes mellitus and lack of association with PAI-1 plasma levels.Semantic proximity Read ↗

Plasminogen activator inhibitor 4G polymorphism is associated with decreased risk of cerebrovascular mortality in older women.Semantic proximity Read ↗

4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly.Semantic proximity Read ↗

PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample.Semantic proximity Read ↗

The association of PAI-1 promoter 4G/5G insertion/deletion polymorphism with myocardial infarction and stroke in young women.Semantic proximity Read ↗

Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke.Semantic proximity Read ↗

The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery DiseaseSemantic proximity Read ↗

Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men.Semantic proximity Read ↗

The 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is not associated with myocardial infarction.Semantic proximity Read ↗

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