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Article

PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample.

Obesity (Silver Spring, Md.) - 1 May 2006

Meigs James B, Dupuis Josée, Liu Chunyu, O'Donnell Christopher J, Fox Caroline S, Kathiresan Sekar, Gabriel Stacey B, Larson Martin G, Yang Qiong, Herbert Alan G, Wilson Peter W F, Feng Dali, Tofler Geoffrey H, Cupples L Adrienne

Abstract excerpt

Elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) increase risk for type 2 diabetes. The PAI-1 4G/5G polymorphism is a major genetic determinant of plasma PAI-1 levels, with 4G/4G homozygotes having elevated PAI-1 levels relative to 5G allele carriers. These observations suggest the hypothesis that the PAI-1 4G/5G polymorphism could be a genetic risk factor for diabetes. We tested this...

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PMID: 16855181
DOI: 10.1038/oby.2006.85

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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