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Article

SMAD4 as a prognostic marker in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2005

Alazzouzi Hafid, Alhopuro Pia, Salovaara Reijo, Sammalkorpi Heli, Järvinen Heikki, Mecklin Jukka-Pekka, Hemminki Akeseli, Schwartz Simo, Aaltonen Lauri A, Arango Diego

Abstract excerpt

More than 50% of patients with Dukes C colorectal cancer have disease recurrence and die within 5 years after surgical removal of their primary tumor. It is currently not possible to distinguish patients with good and bad prognosis. SMAD4 is an important tumor suppressor gene that mediates transforming growth factor-beta superfamily signaling and is located in chromosome 18q21, a region with frequent genetic...

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Share to Chromosomes, Human, Pair 18
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15814640
DOI: 10.1158/1078-0432.CCR-04-1458

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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