Article
Early synaptic defects in tulp1-/- mice.
Investigative ophthalmology & visual science - 1 Jul 2009
Grossman Gregory H, Pauer Gayle J T, Narendra Umadevi, Peachey Neal S, Hagstrom Stephanie A
Abstract excerpt
PURPOSE: Mutations in the photoreceptor-specific tubby-like protein 1 (TULP1) underlie a form of autosomal recessive retinitis pigmentosa. To investigate the role of Tulp1 in the photoreceptor synapse, the authors examined the presynaptic and postsynaptic architecture and retinal function in tulp1(-/-) mice METHODS: The authors used immunohistochemistry to examine tulp1(-/-) mice before retinal degeneration and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
