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Article

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

2 Feb 2017

Abstract excerpt

The primary cilium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understood. In this study, we determine that the tubby family protein TULP3 functions as a general adapter for ciliary trafficking of structurally diverse integral membrane cargo, including multiple reported and...

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PMID: 28154160
DOI: 10.1083/jcb.201607095

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