Article

<i>Ift172</i> conditional knockout mice exhibit rapid retinal degeneration and protein trafficking defects

2017-10-29

Abstract excerpt

Intraflagellar transport (IFT) is a bidirectional transport process that occurs along primary cilia and specialized sensory cilia, such as photoreceptor outer-segments. Genes coding for various IFT components are associated with ciliopathies. Mutations in IFT172 lead to diseases ranging from isolated retinal degeneration to severe syndromic ciliopathies. In this study, we created a mouse model of IFT172 -associa...

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Literature Corpus work: 331a122c-b30b-5fcb-ba15-5f35959f5038
DOI: 10.1101/210617

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