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Article

Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer.

PloS one - 1 Jan 2013

Zhao Yuan, Han Yusong, Zhang Liang, Wang Yichao, Ma Yushui, Zhang Feng, Fu Da, Wang Xiaofeng

Abstract excerpt

CYP2C9 enzyme activity is involved in the metabolism of substances related to colorectal cancer (CRC), and it is functionally linked to a genetic polymorphism. Two allelic variants of the CYP2C9 gene, namely CYP2C9*2 and CYP2C9*3, differ from wild-type CYP2C9*1 by single amino acid substitutions. These mutated alleles encode enzymes with altered properties that are associated with impaired metabolism. In the past...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23577132
DOI: 10.1371/journal.pone.0060607
PMCID: PMC3618415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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