Article
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Carcinogenesis - 1 Nov 2002
Sachse Christoph, Smith Gillian, Wilkie Murray J V, Barrett Jennifer H, Waxman Robin, Sullivan Frank, Forman David, Bishop D Timothy, Wolf C Roland
Abstract excerpt
Susceptibility to colorectal cancer, one of the most common forms of cancer in the Western world, has been associated with several environmental and dietary risk factors. Dietary exposure to food derived heterocyclic amine carcinogens and polycyclic aromatic hydrocarbons have been proposed as specific risk factors. Many polymorphic Phase I and Phase II drug metabolizing enzymes are responsible for the metabolism...
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