Presence of benzo[a]pyrene diol epoxide adducts in target DNA leads to an increase in UV-induced DNA single strand breaks and supF gene mutations.

doi:10.1093/carcin/22.8.1231

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Article

Presence of benzo[a]pyrene diol epoxide adducts in target DNA leads to an increase in UV-induced DNA single strand breaks and supF gene mutations.

Carcinogenesis - 1 Aug 2001

Routledge M N, McLuckie K I, Jones G D, Farmer P B, Martin E A

Abstract excerpt

Exposure to DNA damaging agents and mutagens often occurs as combinations of agents, or as complex mixtures of chemicals. We found that plasmid DNA adducted with benzo[a]pyrene diol epoxide (BPDE) was more susceptible to UV-induced single strand breaks than was control DNA. To determine whether t...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Base Sequence
DNA Adducts
DNA, Single-Stranded
Genes, Suppressor
Molecular Sequence Data
Mutation
RNA, Transfer
Ultraviolet Rays

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