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Article

Light-dependent mutagenesis by benzo[a]pyrene is mediated via oxidative DNA damage.

Environmental and molecular mutagenesis - 1 Oct 2005

Kim Su-Ryang, Kokubo Kiyoko, Matsui Keiko, Yamada Noriyo, Kanke Yusuke, Fukuoka Masamichi, Yamada Masami, Nohmi Takehiko

Abstract excerpt

Benzo[a]pyrene (B[a]P) is an environmental carcinogenic polycyclic aromatic hydrocarbon (PAH). Mammalian enzymes such as cytochrome P-450s and epoxide hydrase convert B[a]P to reactive metabolites that can covalently bind to DNA. However, some carcinogenic compounds that normally require metabolic activation can also be directly photoactivated to mutagens. To examine whether B[a]P is directly mutagenic in the...

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Identifiers

PMID: 15880422
DOI: 10.1002/em.20141

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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