Article
APC binds to the novel protein EB1.
Cancer research - 15 Jul 1995
Su L K, Burrell M, Hill D E, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler K W
Abstract excerpt
Mutations of the APC gene play a critical role in both sporadic and familial forms of colorectal cancer. The vast majority of these mutations result in the loss of the carboxyl terminus of the protein. To further elucidate the function of APC, we searched for cellular proteins that associate with...
Topics
- Adenomatous Polyposis Coli Protein
- Amino Acid Sequence
- Base Sequence
- Blotting, Northern
- Colorectal Neoplasms
- Cytoskeletal Proteins
- DNA-Binding Proteins
- Genes, APC
- Glutathione Transferase
- Humans
- Microtubule-Associated Proteins
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Protein Binding
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid
- Transfection