Article
APC binds to the novel protein EB1.
Cancer research - 15 Jul 1995
Su L K, Burrell M, Hill D E, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler K W
Abstract excerpt
Mutations of the APC gene play a critical role in both sporadic and familial forms of colorectal cancer. The vast majority of these mutations result in the loss of the carboxyl terminus of the protein. To further elucidate the function of APC, we searched for cellular proteins that associate with its carboxyl terminus. One million human cDNA clones were screened with the use of the interaction trap two-hybrid...
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