Article
Cyclooxygenase-2: potential role in regulation of drug efflux and multidrug resistance phenotype.
Current pharmaceutical design - 1 Jan 2004
Sorokin A
Abstract excerpt
Multidrug resistance (MDR) of cancer cells to cytostatic agents is the major obstacle for the succesfull chemotherapy. One of the causes of the development of cellular resistance to a wide variety of drugs is the elevated expression of membrane transporter proteins such as members of ATP binding...
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