Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of resistant HIV mutants during antiretroviral therapy.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000

Ribeiro R M, Bonhoeffer S

Abstract excerpt

HIV drug therapy often fails because of the appearance of multidrug-resistant virus. There are two possible scenarios for the outgrowth of multidrug-resistant virus in response to therapy. Resistant virus may preexist at low frequencies in drug-naive patients and is rapidly selected in the presence of drugs. Alternatively, resistant virus is absent at the start of therapy but is generated by residual viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Computer Simulation
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Models, Genetic

Share to Stochastic Processes

Share to Treatment Failure

Source

Open in PubMed Open full text

Identifiers

PMID: 10884399
DOI: 10.1073/pnas.97.14.7681
PMCID: PMC16603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of resistant HIV mutants during antiretroviral therapy.PMID 10884399Read ↗

Pre–existence and emergence of drug resistance in HIV–1 infectionSemantic proximity Read ↗

Comparison of different treatment regimens for the emergence of new resistance under therapy.Semantic proximity Read ↗

Mathematical approaches in the study of viral kinetics and drug resistance in HIV-1 infection.Semantic proximity Read ↗

Mechanism of HIV antiretroviral drugs progress toward drug resistance.Semantic proximity Read ↗

[Molecular mechanisms for the emergence of drug-resistant HIV-1].Semantic proximity Read ↗

Persistence of primary drug resistance among recently HIV-1 infected adults.Semantic proximity Read ↗

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.Semantic proximity Read ↗

Mutation takes no vacation: can structured treatment interruptions increase the risk of drug-resistant HIV-1?Semantic proximity Read ↗

Evolution of drug-resistant viral populations during interruption of antiretroviral therapy.Semantic proximity Read ↗

Development of drug resistance mutations in patients on highly active antiretroviral therapy: does competitive advantage drive evolution.Semantic proximity Read ↗

Fitness of drug resistant HIV-1: methodology and clinical implicationsSemantic proximity Read ↗

Timing the emergence of resistance to anti-HIV drugs with large genetic barriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.