Article
Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR.
Nucleic acids research - 15 Nov 2003
Ruggiero Tina, Olivero Martina, Follenzi Antonia, Naldini Luigi, Calogero Raffaele, Di Renzo Maria Flavia
Abstract excerpt
A high level of genetic instability might cause mutations to accumulate in tumours. Microsatellite instability (MSI), due to defects of the DNA mismatch repair system, affects in particular repeat sequences (microsatellites) scattered throughout the genome. By scanning transcriptome databases, we found that microsatellites in the human genome are less numerous in coding DNA than in the 3'-untranslated region...
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