Article

Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

2020-11-23

Abstract excerpt

The TP53 gene encodes the tumor suppressor p53, which is functionally inactivated in many human cancers. Numerous studies found that overexpression of specific microRNAs or RNA-binding proteins can alter p53 expression through binding to cis -regulatory elements in the TP53 3′ untranslated region (3′UTR). Although these studies suggested that 3′UTR-mediated p53 expression regulation could play a role in tumorig...

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Literature Corpus work: f61785bc-9b1e-53c0-a202-98c28ef6fb57
DOI: 10.1101/2020.11.23.394197

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