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Article

Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation.

European journal of immunology - 1 May 2001

Vinuesa C G, Sunners Y, Pongracz J, Ball J, Toellner K M, Taylor D, MacLennan I C, Cook M C

Abstract excerpt

X-linked immunodeficient (Xid) mice carry a Bruton's tyrosine kinase (Btk) mutation and exhibit a selective failure to produce antibodies against bacterial capsular polysaccharides. Studies in vitro point to a fundamental survival defect of Xid B cells after receptor cross-linking by thymus-independent type-2 (TI-2) antigen because B cells undergo apoptosis without proliferating. We describe results from a novel...

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Source

Identifiers

PMID: 11465091
DOI: 10.1002/1521-4141(200105)31:5<1340::AID-IMMU1340>3.0.CO;2-H

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation.PMID 11465091Read ↗

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