Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2013

Crane Deborah D, Griffin Amanda J, Wehrly Tara D, Bosio Catharine M

Abstract excerpt

B1a cells are an important source of natural Abs, Abs directed against T-independent Ags, and are a primary source of IL-10. Bruton's tyrosine kinase (btk) is a cytoplasmic kinase that is essential for mediating signals from the BCR and is critical for development of B1a cells. Consequentially, animals lacking btk have few B1a cells, minimal Ab responses, and can preferentially generate Th1-type immune responses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Bacterial
Share to B-Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exudates and Transudates

Share to Francisella tularensis

Share to Natural Killer T-Cells

Share to Peritoneum

Share to Th1 Cells

Share to Tularemia

Source

Open in PubMed Open full text

Identifiers

PMID: 23378429
DOI: 10.4049/jimmunol.1202697
PMCID: PMC3594638

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses.PMID 23378429Read ↗

Single-cell resolution map of innate-like lymphocyte response to <i>Francisella tularensis</i> infection reveals MAIT cells’ role in protection from tularemia-like diseaseSemantic proximity Read ↗

<i>Nfkbid</i> is required for immunity and antibody responses to <i>Toxoplasma gondii</i>Semantic proximity Read ↗

Exploitation of Host Cell Biology and Evasion of Immunity by Francisella TularensisSemantic proximity Read ↗

Enhanced immunogenicity of the Brucella A19 ΔbtpB mutant leads to accelerated clearance in the host.Semantic proximity Read ↗

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.Semantic proximity Read ↗

Identification of a Novel Francisella tularensis Factor Required for Intramacrophage Survival and Subversion of Innate Immune ResponseSemantic proximity Read ↗

Intraperitoneal treatment with antimicrobial peptide rescues mice from a pulmonary <i>Francisella</i> infectionSemantic proximity Read ↗

Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation.Semantic proximity Read ↗

Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil ApoptosisSemantic proximity Read ↗

Repression of inflammasome by Francisella tularensis during early stages of infection.Semantic proximity Read ↗

Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4Semantic proximity Read ↗

Comparative analysis of absent in melanoma 2-inflammasome activation in Francisella tularensis and Francisella novicidaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.