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Article

Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes.

Science (New York, N.Y.) - 16 Jul 1993

Thomas J D, Sideras P, Smith C I, Vorechovský I, Chapman V, Paul W E

Abstract excerpt

Mice that bear the X-linked immunodeficiency (xid) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens. A backcross of 1114 progeny revealed the colocalization of xid with Bruton's agammaglobulinemia tyrosine kinase (btk) gene, which is implicated in the human immune deficiency, X-linked agammaglobulinemia. Mice that carry xid have a...

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Identifiers

PMID: 8332900
DOI: 10.1126/science.8332900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes.PMID 8332900Read ↗

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Btk dosage determines sensitivity to B cell antigen receptor cross-linking.Semantic proximity Read ↗

X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.Semantic proximity Read ↗

X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease.Semantic proximity Read ↗

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid miceSemantic proximity Read ↗

Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).Semantic proximity Read ↗

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.Semantic proximity Read ↗

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