Article
Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers.
Oncogene - 9 Nov 2000
Ahomadegbe J C, Tourpin S, Kaghad M, Zelek L, Vayssade M, Mathieu M C, Rochard F, Spielmann M, Tursz T, Caput D, Riou G, Bénard J
Abstract excerpt
The p73 gene is a p53 homologue located at 1p36-33, a region submitted to deletions in breast cancer (BC) and putatively imprinted. To study whether p73 was associated with breast carcinogenesis, loss of heterozygosity (LOH), allele expression and transcript levels were assessed in 59 BC, including 39 BC presenting no inflammatory symptoms (NBC) and 20 inflammatory BC (IBC). IBC is a rare but aggressive form of...
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