Article
Analysis of ubiquitination in vivo using a transgenic mouse model.
BioTechniques - 1 Jul 2001
Tsirigotis M, Thurig S, Dubé M, Vanderhyden B C, Zhang M, Gray D A
Abstract excerpt
The primary pathway for the proteolytic destruction of cellular proteins is through ubiquitin-mediated targeting to the proteasome. This pathway is pivotal not only in the elimination of damaged or misfolded proteins but also in the temporal, developmental, or signal-mediated destruction of normal cellular substrates. The list of known substrates of the ubiquitin/proteasome pathway is long, but most substrates...
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