Article
A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2005
Kumarapeli Asangi R K, Horak Kathleen M, Glasford Joseph W, Li Jie, Chen Quanhai, Liu Jinbao, Zheng Hanqiao, Wang Xuejun
Abstract excerpt
Ubiquitin-proteasome system (UPS) mediated proteolysis is responsible for the degradation of majority of cellular proteins, thereby playing essential roles in maintaining cellular homeostasis and regulating a number of cellular functions. UPS dysfunction was implicated in the pathogenesis of numerous disorders, including neurodegenerative disease, muscular dystrophy, and a subset of cardiomyopathies. However,...
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