Article
The mutation of Japanese encephalitis virus envelope protein residue 389 attenuates viral neuroinvasiveness.
Virology journal - 5 Jun 2024
Huang Rong, He Yajing, Zhang Chenghua, Luo Yue, Chen Chen, Tan Ning, Ren Yang, Xu Kui, Yuan Lei, Yang Jian
Abstract excerpt
The envelope (E) protein of the Japanese encephalitis virus (JEV) is a key protein for virus infection and adsorption of host cells, which determines the virulence of the virus and regulates the intensity of inflammatory response. The mutation of multiple aa residues in the E protein plays a critical role in the attenuated strain of JEV. This study demonstrated that the Asp to Gly, Ser, and His mutation of the...
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