Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Flavivirus Attenuation Markers Identified in the Envelope Protein of Alfuy Virus.

Viruses - 20 Jan 2021

Westlake Daniel, Bielefeldt-Ohmann Helle, Prow Natalie A A, Hall Roy A A

Abstract excerpt

Alfuy (ALFV) is an attenuated flavivirus related to the Murray Valley encephalitis virus (MVEV). We previously identified markers of attenuation in the envelope (E) protein of the prototype strain (ALFV3929), including the hinge region (E273-277) and lack of glycosylation at E154-156. To further determine the mechanisms of attenuation we assessed ALFV3929 binding to glycosaminoglycans (GAG), a known mechanism of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Glycosaminoglycans
Share to Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin

Share to Protein Domains

Share to Serial Passage

Share to Viral Envelope Proteins

Share to Viral Plaque Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 33498300
DOI: 10.3390/v13020147
PMCID: PMC7909262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Flavivirus Attenuation Markers Identified in the Envelope Protein of Alfuy Virus.PMID 33498300Read ↗

A Molecular Determinant of West Nile Virus Secretion and Morphology as a Target for Viral Attenuation.Semantic proximity Read ↗

Mutation of lysine 396 of the fusion protein reduces its binding affinity with integrin αVβ1 and leads to attenuation of avian metapneumovirus subtype B.Semantic proximity Read ↗

Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein.Semantic proximity Read ↗

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis.Semantic proximity Read ↗

Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors.Semantic proximity Read ↗

Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphavirusesSemantic proximity Read ↗

Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.Semantic proximity Read ↗

Evolution subverting essentiality: Dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virusSemantic proximity Read ↗

Role of N-linked glycosylation of the Hendra virus fusion protein.Semantic proximity Read ↗

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquitoSemantic proximity Read ↗

Tyrosine 78 of premembrane protein is essential for assembly of West Nile virus.Semantic proximity Read ↗

Dengue type four viruses with E-Glu345Lys adaptive mutation from MRC-5 cells induce low viremia but elicit potent neutralizing antibodies in rhesus monkeys.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.