Article
In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene.
Molecular genetics and metabolism - 1 Jul 2001
Lambert D M, Mamer O A, Akerman B R, Choinière L, Gaudet D, Hamet P, Treacy E P
Abstract excerpt
Trimethylaminuria (TMAU) results from an accumulation of an excessive amount of unoxidized trimethylamine that is excreted in urine and body secretions. Mutations of the flavin-containing monooxygenase 3 (FMO3) gene (a hepatic phase I drug-metabolizing enzyme) account for the severe recessively encoded form of this condition. We have previously described a number of FMO3 polymorphisms which in vitro exhibit...
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