Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria.

Pharmacogenetics - 1 Aug 2003

Zhang Jun, Tran Quyen, Lattard Virginie, Cashman John R

Abstract excerpt

The primary genetic form of trimethylaminuria (TMAU) is caused by inherited defects in the flavin-containing monooxygenase 3 (FMO3) gene. Defective FMO3 has a decreased ability to catalyze the N-oxygenation of the dietary-derived malodourous amine, trimethylamine. We report two novel deleterious mutations identified in two unrelated individuals affected by the disorder. Sequence analysis of the FMO3 coding exons...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Metabolism, Inborn Errors

Share to Methylamines

Share to Oxygenases

Share to Sequence Deletion

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 12893987
DOI: 10.1097/00008571-200308000-00007

Genes

FMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria.PMID 12893987Read ↗

Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.Semantic proximity Read ↗

Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria.Semantic proximity Read ↗

Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.Semantic proximity Read ↗

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources.Semantic proximity Read ↗

Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.Semantic proximity Read ↗

Two novel mutations of the FMO3 gene in a proband with trimethylaminuria.Semantic proximity Read ↗

Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.Semantic proximity Read ↗

Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort.Semantic proximity Read ↗

Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome.Semantic proximity Read ↗

Trimethylaminuria and a human FMO3 mutation database.Semantic proximity Read ↗

Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.Semantic proximity Read ↗

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.