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Article

Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A.

Scientific reports - 6 Jun 2017

Chen Ping, Zhou Zizhang, Yao Xia, Pang Shu, Liu Meijing, Jiang Weirong, Jiang Jin, Zhang Qing

Abstract excerpt

Hedgehog (Hh) signaling plays a pivotal role in animal development and its deregulation in humans causes birth defects and several types of cancer. Protein Kinase A (PKA) modulates Hh signaling activity through phosphorylating the transcription factor Cubitus interruptus (Ci) and G protein coupled receptor (GPCR) family protein Smoothened (Smo) in Drosophila, but how PKA activity is regulated remains elusive....

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Identifiers

PMID: 28588207
DOI: 10.1038/s41598-017-03165-2
PMCID: PMC5460166

Genes

RNGTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A.PMID 28588207Read ↗

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