Article
A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.
Mutation research - 21 Oct 1998
Ludwig D L, MacInnes M A, Takiguchi Y, Purtymun P E, Henrie M, Flannery M, Meneses J, Pedersen R A, Chen D J
Abstract excerpt
Apurinic/apyrimidinic endonuclease (here designated APE/REF) carries out repair incision at abasic or single-strand break damages in mammals. This multifunctional protein also has putative role(s) as a cysteine 'reducing factor' (REF) in cell-stress transcriptional responses. To assess the signif...
Topics
- Alleles
- Animals
- Base Sequence
- Blastocyst
- Carbon-Oxygen Lyases
- DNA Primers
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- Embryonic and Fetal Development
- Female
- Gamma Rays
- Gene Targeting
- Genetic Vectors