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Article

A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.

Mutation research - 21 Oct 1998

Ludwig D L, MacInnes M A, Takiguchi Y, Purtymun P E, Henrie M, Flannery M, Meneses J, Pedersen R A, Chen D J

Abstract excerpt

Apurinic/apyrimidinic endonuclease (here designated APE/REF) carries out repair incision at abasic or single-strand break damages in mammals. This multifunctional protein also has putative role(s) as a cysteine 'reducing factor' (REF) in cell-stress transcriptional responses. To assess the significance of APE/REF for embryonic teratogenesis we constructed a more precisely targeted Ape/Ref-deficient genotype in...

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PMID: 9806499
DOI: 10.1016/s0921-8777(98)00039-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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