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Article

The contribution of metal ions to the conformational stability of ribonuclease T1: crystal versus solution.

European journal of biochemistry - 1 Jul 2001

Deswarte J, De Vos S, Langhorst U, Steyaert J, Loris R

Abstract excerpt

In the crystalline state, ribonuclease T1 binds calcium ions at different lattice-dependent positions. In solution, its conformational stability is also remarkably increased in the presence of divalent metal ions. Combining urea unfolding studies and X-ray crystallography, we compared the presence of several metal ions at specific sites in the protein to their contribution to the overall stabilizing effect in...

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PMID: 11453993
DOI: 10.1046/j.1432-1327.2001.02310.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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