Article
[Evaluation of helper T lymphocyte subpopulations: naive (CD4+CD45RA+), memory (CD4+CD45RO+) and co-expression of phenotypes CD45RA+ and CD45RO+ in preclinical phases of diabetes type 1 (prediabetes)].
Przeglad lekarski - 1 Jan 2001
Kretowski A, Kinalska I
Abstract excerpt
There is an increasing evidence that T helper lymphocytes (CD4+) play a key role in the etiopathogenesis of type 1 diabetes. The aim of the present study was to evaluate the presence of T helper lymphocyte subpopulations: naive (CD4+CD45RA+), memory cells (CD4+CDRO+) and lymphocytes coexpressing both studied phenotypes (CD4+CD45RA+CD45RO+) in subjects at risk of type 1 diabetes (first degree relatives of IDDM...
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