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Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.

Diabetes - 1 Dec 2005

Durinovic-Belló Ivana, Jelinek Eva, Schlosser Michael, Eiermann Thomas, Boehm Bernhard O, Karges Wolfram, Marchand Luc, Polychronakos Constantin

Abstract excerpt

A variable number of tandem repeats (VNTR) polymorphism upstream of the insulin promoter is strongly associated with type 1 diabetes. The short class I alleles are predisposing and the long class III alleles are protective. As a possible mechanism for this effect, we previously reported a two- to threefold higher insulin transcription from class III than from class I chromosomes in thymus where insulin is...

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PMID: 16306335
DOI: 10.2337/diabetes.54.suppl_2.s18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.PMID 16306335Read ↗

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