Article
Mice with mutations in the mahogany gene Atrn have cerebral spongiform changes.
Journal of neuropathology and experimental neurology - 1 Jul 2001
Bronson R T, Donahue L R, Samples R, Kim J H, Naggert J K
Abstract excerpt
A new mutation characterized by mahogany coat color, sprawling gait, tremors, and severe vacuolization of cerebrum, brainstem, granular layer of cerebellum and spinal cord was discovered in a stock of Mus castaneus mice. Tests for allelism using mice homozygous for 2 known mahogany attractin (Atrnmg) mutants showed that the new mutation was an allele of Atrnmg. Northern analysis showed no expression of Atrn in...
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