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Article

Mahogany/attractin: en route from phenotype to function.

Trends in cardiovascular medicine - 1 Feb 2000

Gunn T M, Barsh G S

Abstract excerpt

The mouse mahogany mutation affects melanocortin signaling pathways that regulate energy homeostasis and hair color. The gene mutated in mahogany mice encodes attractin, a large transmembrane protein that is broadly expressed and conserved among multicellular animals. Mouse attractin is likely to have additional roles outside melanocortin signaling, and cloning of the gene provides information that can be used to...

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Identifiers

PMID: 11150734
DOI: 10.1016/s1050-1738(00)00052-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mahogany/attractin: en route from phenotype to function.PMID 11150734Read ↗

The mouse mahogany locus encodes a transmembrane form of human attractin.Semantic proximity Read ↗

The mahogany mouse mutation: further links between pigmentation, obesity and the immune system.Semantic proximity Read ↗

Attractin: cautionary tales for therapeutic intervention in molecules with pleiotropic functionality.Semantic proximity Read ↗

A biochemical function for attractin in agouti-induced pigmentation and obesity.Semantic proximity Read ↗

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.Semantic proximity Read ↗

Accessory proteins for melanocortin signaling: attractin and mahogunin.Semantic proximity Read ↗

Molecular and phenotypic analysis of Attractin mutant mice.Semantic proximity Read ↗

Genetic analysis of attractin homologs.Semantic proximity Read ↗

Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.Semantic proximity Read ↗

Mice with mutations in the mahogany gene Atrn have cerebral spongiform changes.Semantic proximity Read ↗

Attractin-Like Protein 1 (ATRNL1): An Essential Partner of MC4R to Regulate Body WeightSemantic proximity Read ↗

Spongiform degeneration in mahoganoid mutant mice.Semantic proximity Read ↗

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