Article
Insertional mutation of the Attractin gene in the black tremor hamster.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2002
Kuramoto Takashi, Nomoto Tomoko, Fujiwara Akira, Mizutani Makoto, Sugimura Takashi, Ushijima Toshikazu
Abstract excerpt
The hamster black tremor (bt) mutation induces a black coat color and a defective myelination in the central nervous system (CNS) that manifests as a tremor. On the other hand, loss-of-function mutations of the Attractin (Atrn) gene, such as Atrnmg, Atrnmg-L, and Atrnmg-3J in mice, and Atrnzi in rats, induce both darkening of coat color and hypomyelination and vacuolation in the CNS. The close resemblance of the...
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