Article
A biochemical function for attractin in agouti-induced pigmentation and obesity.
Nature genetics - 1 Jan 2001
He L, Gunn T M, Bouley D M, Lu X Y, Watson S J, Schlossman S F, Duke-Cohan J S, Barsh G S
Abstract excerpt
Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (A(y)) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrn(mg-3J)/ Atrn(mg-3J)) mutant mice blocks the pleiotropic effects of A(y). Here we...
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