Article
Spongiform degeneration in mahoganoid mutant mice.
Science (New York, N.Y.) - 31 Jan 2003
He Lin, Lu Xin-Yun, Jolly Aaron F, Eldridge Adam G, Watson Stanley J, Jackson Peter K, Barsh Gregory S, Gunn Teresa M
Abstract excerpt
mahoganoid is a mouse coat-color mutation whose pigmentary phenotype and genetic interactions resemble those of Attractin (Atrn). Atrn mutations also cause spongiform neurodegeneration. Here, we show that a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion diseases but without accumulation of protease-resistant prion protein. The gene mutated in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.