Article
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2001
Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh G S, Nagao M, Ushijima T, Serikawa T
Abstract excerpt
The rat zitter (zi) mutation induces hypomyelination and vacuolation in the central nervous system (CNS), which result in early-onset tremor and progressive flaccid paresis. By positional cloning, we found a marked decrease in Attractin (Atrn) mRNA in the brain of the zi/zi rat and identified zi as an 8-bp deletion at a splice donor site of Atrn. Atrn has been known to play multiple roles in regulating...
Topics
- Agouti Signaling Protein
- Animals
- Animals, Genetically Modified
- Axons
- Brain Chemistry
- Central Nervous System Diseases
- Chromosome Mapping
- Chromosomes, Human, Pair 20
- DNA, Complementary
- Energy Metabolism