Article
A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity.
The Journal of clinical endocrinology and metabolism - 1 Jul 2001
Mergen M, Mergen H, Ozata M, Oner R, Oner C
Abstract excerpt
Mutations in the melanocortin 4 receptor gene (MC4R) are the most common cause of monogenic human obesity. As part of our ongoing project entitled 'Turkish Obesity Genome Study' we determined the nucleotide sequence of the entire coding region of the MC4R gene in 40 morbidly obese subjects from independent families. Here we report a novel heterozygous mutation (N274S) in an adult female obese individual (age: 52...
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