Article
A structure-based model for the synthesis and hydrolysis of ATP by F1-ATPase.
Cell - 21 Oct 2005
Gao Yi Qin, Yang Wei, Karplus Martin
Abstract excerpt
Many essential functions of living cells are performed by nanoscale protein motors. The best characterized of these is F(o)F1-ATP synthase, the smallest rotary motor. This rotary motor catalyzes the synthesis of ATP with high efficiency under conditions where the reactants (ADP, H2PO4(-)) and the product (ATP) are present in the cell at similar concentrations. We present a detailed structure-based kinetic model...
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