Article
Mutation frequency and type during ageing in mouse seminiferous tubules.
Mechanisms of ageing and development - 1 Sept 2001
Martin S L, Hopkins C L, Naumer A, Dollé M E, Vijg J
Abstract excerpt
Mutations arise in the germline by errors of replication, recombination and repair, and the movement of transposable elements. Transgenic mice bearing reporter genes such as lacZ have proven useful for measurements of spontaneous and induced mutation frequencies, as well as studies of the effects of ageing. In this study, testicular DNA from lacZ transgenic mice was examined for age-related effects on mutation...
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