Article
Familial CD8 deficiency due to a mutation in the CD8 alpha gene.
The Journal of clinical investigation - 1 Jul 2001
de la Calle-Martin O, Hernandez M, Ordi J, Casamitjana N, Arostegui J I, Caragol I, Ferrando M, Labrador M, Rodriguez-Sanchez J L, Espanol T
Abstract excerpt
CD8 glycoproteins play an important role in both the maturation and function of MHC class I-restricted T lymphocytes. A 25-year-old man, from a consanguineous family, with recurrent bacterial infections and total absence of CD8(+) cells, was studied. Ab deficiencies and ZAP-70 and TAP defects wer...
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