Article
T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1995
Bachmann M F, Oxenius A, Mak T W, Zinkernagel R M
Abstract excerpt
The CD4 and CD8 molecules are involved in T cell differentiation and activation. Nevertheless, efficient thymic maturation of helper T cells has been shown in the absence of the CD4 molecule. These CD4-deficient helper T cells expressed alpha beta-TCR and were able to control Leishmania infections and to mediate Ab class switch. Using mice deficient for the CD8 alpha-chain, we investigated whether a similar...
Topics
- Animals
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cytotoxicity Tests, Immunologic
- Flow Cytometry
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Isoantigens
- Lymphocyte Activation
- Lymphocytic choriomeningitis virus