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Article

T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1995

Bachmann M F, Oxenius A, Mak T W, Zinkernagel R M

Abstract excerpt

The CD4 and CD8 molecules are involved in T cell differentiation and activation. Nevertheless, efficient thymic maturation of helper T cells has been shown in the absence of the CD4 molecule. These CD4-deficient helper T cells expressed alpha beta-TCR and were able to control Leishmania infections and to mediate Ab class switch. Using mice deficient for the CD8 alpha-chain, we investigated whether a similar...

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PMID: 7561076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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