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Article

Recurrent Respiratory Infections Revealing CD8α Deficiency.

Journal of clinical immunology - 1 Nov 2015

Dumontet Erwan, Osman Jennifer, Guillemont-Lambert Nathalie, Cros Guilhem, Moshous Despina, Picard Capucine

Abstract excerpt

CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes...

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Share to CD8 Antigens
Share to Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Subsets

Share to Mutation, Missense

Share to Receptors, Antigen, T-Cell

Share to Recurrence

Share to Respiratory Tract Infections

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 26563160
DOI: 10.1007/s10875-015-0213-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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