Article
Expression of CD8beta and alteration of cell surface phenotype in adult T-cell leukaemia cells.
British journal of haematology - 1 Jul 1997
Joh T, Yamada Y, Seto M, Kamihira S, Tomonaga M
Abstract excerpt
Typical adult T-cell leukaemia (ATL) cells have a CD4+ CD8- cell surface phenotype, but atypical phenotypes such as CD4+ CD8+ and CD4- CD8+ have also been reported. The CD8 molecule is composed of alpha and beta chains and commonly used monoclonal antibodies against CD8 molecule detect only CD8alpha. Since it has been reported that CD8alpha can be induced in mature CD4+ T cells by cell activation, but not...
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