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Article

Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells.

Experimental hematology - 1 May 2008

Orschell Christie M, Borneo Jovencio, Munugalavadla Veerendra, Ma Peilin, Sims Emily, Ramdas Baskar, Yoder Mervin C, Kapur Reuben

Abstract excerpt

OBJECTIVE: Src family kinases (SFK) have been implicated in regulating growth factor and integrin-induced proliferation, migration, and gene expression in multiple cell types. However, little is known about the role of these kinases in the growth, homing, and engraftment potential of hematopoietic stem and progenitor cells. RESULTS: Here we show that loss of hematopoietic-specific SFKs Hck, Fgr, and Lyn results...

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Source

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Identifiers

PMID: 18346837
DOI: 10.1016/j.exphem.2008.01.002
PMCID: PMC4378689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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